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Updated: Aug 19, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
Predisposing and precipitating factors for suicide among alcoholics: empirical review and conceptual integration
Kenneth R Conner1, Paul R Duberstein
1Center for the Study and Prevention of Suicide and Laboratory of Personality and Development, Department of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. Kenneth_conner@urmc.rochester.edu
Abstract:
Alcohol dependence is a potent risk factor for suicide. Accordingly, alcoholics should be targeted in suicide prevention efforts. This article reviews the literature on suicide among alcoholics and provides a model that may inform research, clinical work, and prevention efforts. In this model, we propose that aggression/impulsivity, severe alcoholism, negative affect, and hopelessness are key predisposing factors for suicide among alcoholics. We propose that major depressive episodes and stressful life events, particularly interpersonal difficulties, are key precipitating factors. We also integrate these constructs in a model that proposes that many acts of suicide among alcoholics may be viewed as acts of reactive aggression executed in the midst of distress over a lost or threatened relationship. Empirical evidence for the model is discussed along with its limitations. The next generation of research on alcoholism and suicide should include a focus on the interpersonal anlage of suicide in this population.
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