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Related Experiment Videos

Hemodilution with lactated Ringer's solution causes hypocoagulability in rabbits.

Vance G Nielsen1

  • 1Department of Anesthesiology, Division of Cardiothoracic Anesthesia, The University of Alabama at Birmingham, Alabama 35249-6810, USA. vance.nielsen@ccc.uab.edu

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|May 29, 2004
PubMed
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Hemodilution using lactated Ringer's solution in rabbits surprisingly caused hypocoagulability, not hypercoagulability. This effect resulted from a greater reduction in procoagulant factors than anticoagulants.

Area of Science:

  • Physiology
  • Hematology
  • Surgical Research

Background:

  • Hemodilution (HD) is often linked to hypercoagulability.
  • The specific impact of lactated Ringer's solution (LR) on coagulation requires further investigation.

Purpose of the Study:

  • To investigate the effect of HD with LR on coagulation parameters in rabbits.
  • To determine if HD with LR induces hypercoagulability or hypocoagulability.

Main Methods:

  • Sedated rabbits (n=12) underwent HD, replacing 40% of blood volume with LR.
  • Assessed procoagulant and anticoagulant activities, activated coagulation time, and thrombelastography before and after HD.

Main Results:

  • HD significantly decreased procoagulant activities (tissue factor, factor VIII, factor X) more than anticoagulant activities (tissue factor pathway inhibitor, antithrombin, protein C).

Related Experiment Videos

  • Activated coagulation time and thrombelastography indicated a significant decrease in hemostatic function post-HD.

    • Conclusions:

    • Hemodilution with lactated Ringer's solution induced hypocoagulability in rabbits.
    • The mechanism involves a greater reduction in procoagulant activity compared to anticoagulant activity.