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Elevated triiodothyronine in psychopathy - possible physiological mechanisms

H Soderstrom1, A Forsman

  • 1National Board of Forensic Medicine, Department of Forensic Psychiatry, Göteborg, Sweden. henrik.soderstrom@rmv.se

Journal of Neural Transmission (Vienna, Austria : 1996)
|May 29, 2004
PubMed

We assessed a total range of peripheral thyroid hormone fractions, binding globulins, and thyroid-active antibodies in 37 medication-free, violent or sexual offenders, aged 17-45 years, to describe possible mechanisms involved in the thyroid metabolism of aggressive men. The ratio between T3 and T4 correlated with ratings of psychopathy, indicating increased peripheral deiodination as a biological covariate to callous personality traits. Autoimmune antibodies, hepatic failure, abnormal binding globulins, or substance abuse did not affect the association.

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