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A Murine Model of Hemodialysis Access-Related Hand Dysfunction
Published on: May 31, 2022
Associations with predialysis vascular access management
Timmy Lee1, Jill Barker, Michael Allon
1Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, USA.
Insights
Despite K/DOQI guidelines, many hemodialysis patients start treatment with catheters. Patients with diabetes had better vascular access management, highlighting the need for early nephrology referral for non-diabetic chronic kidney disease patients to increase fistula use.
Area of Science:
- Nephrology
- Vascular Surgery
- Public Health
Background:
- Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines promote arteriovenous fistulae for hemodialysis.
- Optimal outcomes necessitate predialysis nephrologist follow-up, vascular access placement, and maturation.
Purpose of the Study:
- To assess clinical factors influencing predialysis vascular access management in incident hemodialysis patients.
- To evaluate adherence to K/DOQI guidelines regarding vascular access for new dialysis patients.
Main Methods:
- Retrospective analysis of 157 incident hemodialysis patients over a 2-year period.
- Assessment of predialysis nephrology follow-up, vascular access surgery, and initial dialysis access type.
- Comparison of outcomes between diabetic and non-diabetic patients.
Main Results:
- Only 35% of patients initiated dialysis with permanent access; 67.3% of these were fistulae.
- Diabetic patients showed significantly higher rates of predialysis nephrology follow-up (81.5%), surgery (56.5%), and permanent access (43.5%) compared to non-diabetics.
- Patient age, sex, and race did not predict predialysis access management.
Conclusions:
- A significant majority (65%) of incident hemodialysis patients started treatment with a catheter, indicating challenges in meeting K/DOQI goals.
- Diabetes was associated with improved predialysis vascular access management and higher fistula utilization.
- Early nephrology referral for non-diabetic chronic kidney disease patients is crucial to enhance arteriovenous fistula use.
Background:
The Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines encourage increasing the proportion of arteriovenous fistulae among incident hemodialysis patients. Achieving optimal outcomes requires predialysis out-patient follow-up by a nephrologist, predialysis placement of a vascular access, and adequate maturation of the vascular access.
Methods:
We assessed the effect of clinical factors on predialysis vascular access management in all incident hemodialysis patients at a single institution during a 2-year period.
Results:
Of 157 patients initiating dialysis therapy from January 1, 2001, to December 31, 2002, a total of 73.2% had predialysis follow-up by a nephrologist, 46.5% had predialysis vascular access surgery, and 35.0% initiated their first dialysis session with a permanent access. Among patients using a permanent access on their first dialysis session, 67.3% used a fistula. Patients with diabetes were more likely than those without diabetes to have predialysis nephrology follow-up (81.5% versus 61.5%; P = 0.005), undergo predialysis vascular access surgery (56.5% versus 32.3%; P = 0.003), and initiate their first dialysis session with a fistula or graft (43.5% versus 23.1%; P = 0.008). Duration of predialysis nephrology follow-up was similar between patients with and without diabetes (median, 412 versus 300 days; P = 0.27). Patient age, sex, and race were not predictive of predialysis access management.
Conclusion:
Despite attempts to follow the K/DOQI guidelines, 65% of incident hemodialysis patients initiated their first dialysis treatment with a catheter. Patients with diabetes were significantly more likely to have predialysis follow-up by a nephrologist and thus more likely to initiate their first dialysis session with a permanent access. Emphasis on early referral of patients with chronic kidney disease without diabetes to nephrologists may increase fistula use among incident hemodialysis patients.
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