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Related Experiment Videos

Obsessive-compulsive disorder.

M Zetin1, M A Kramer

  • 1Department of Psychiatry, University of California, Medical Center, Irvine, Orange 92668.

Hospital & Community Psychiatry
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

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Obsessive-compulsive disorder (OCD) is common and challenging to treat. New serotonergic antidepressants and behavioral therapy show promise for managing OCD and related conditions.

Area of Science:

  • Psychiatry
  • Neuroscience
  • Clinical Psychology

Background:

  • Obsessive-compulsive disorder (OCD) presents a significant clinical challenge, often proving resistant to conventional psychotherapies and medications.
  • Recent data highlight OCD's prevalence and frequent comorbidity with conditions like phobia, depression, and alcohol abuse.

Observation:

  • A review of current research examines the spectrum of OCD and related disorders.
  • Studies indicate responsiveness to novel serotonergic antidepressants and established behavioral therapy techniques.

Findings:

  • Selective serotonin reuptake inhibitors (SSRIs), initially developed for depression, demonstrate efficacy in treating OCD symptoms.
  • Clomipramine has shown the most significant positive outcomes in extensive clinical trials for OCD treatment.

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  • The shared effectiveness of SSRIs in both antidepressant and antiobsessional roles suggests underlying common biological mechanisms across these disorders.

    • Implications:

    • Long-term pharmacologic management, particularly with SSRIs, is often necessary for patients with OCD.
    • Behavioral therapy represents a viable and successful adjunct or alternative treatment modality for OCD.
    • Understanding shared biological factors could lead to more targeted and effective therapeutic strategies for a range of psychiatric conditions.