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Thermodynamic modeling of donor splice site recognition in pre-mRNA

Jeffrey A Garland1, Daniel P Aalberts

  • 1Physics Department, Williams College, Williamstown, Massachusetts 01267, USA.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|June 1, 2004
PubMed

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
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