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Chronic thyroiditis: thyroid function and histologic correlations in 601 cases.
Y Mizukami1, T Michigishi, M Kawato
1Department of Nuclear Medicine, Kanazawa University Hospital, Japan.
Human Pathology
|September 1, 1992
Summary
Histologic findings in chronic thyroiditis correlate with thyroid function. Oxyphilic and focal types are often hypothyroid, while hyperplastic types are typically hyperthyroid, aiding diagnosis.
Area of Science:
- Endocrinology
- Pathology
- Internal Medicine
Background:
- Chronic thyroiditis encompasses diverse histological subtypes.
- Thyroid dysfunction is a common clinical manifestation.
Purpose of the Study:
- To investigate the correlation between histological subtypes of chronic thyroiditis and thyroid function.
- To assess the utility of thyroid needle biopsy in evaluating thyroid function.
Main Methods:
- Histological classification of chronic thyroiditis into oxyphilic, mixed, focal, and hyperplastic groups.
- Assessment of thyroid function based on serum triiodothyronine (T3), thyroxine (T4), thyrotropin (TSH) levels, and thyrotropin-releasing hormone (TRH) tests.
- Correlation of histological findings with thyroid function status (hyperthyroid, euthyroid, hypothyroid).
Main Results:
- Oxyphilic group (85%) predominantly hypothyroid; Focal group (83%) predominantly euthyroid.
- Hyperplastic group (85%) predominantly hyperthyroid; Mixed group showed varied thyroid function.
- Latent hypothyroidism increased with cell infiltration severity in the focal group.
Conclusions:
- Histological subtype is a significant predictor of thyroid function in chronic thyroiditis.
- Thyroid needle biopsy is valuable for both diagnosis and functional assessment.
- Understanding these correlations aids in identifying causes of thyroid dysfunction.