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Updated: Aug 24, 2026

Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers
Published on: August 31, 2021
Direct observation of anisotropic interparticle forces in nematic colloids with optical tweezers
Makoto Yada1, Jun Yamamoto, Hiroshi Yokoyama
1Yokoyama Nano-structured Liquid Crystal Project, ERATO, Japan Science and Technology Corporation, 5-9-9 Tokodai, Tsukuba, Ibaraki, 300-2635, Japan.
Abstract:
Interparticle forces in a nematic liquid-crystal colloid have been directly observed by the dual beam laser trapping method with pN sensitivity. We introduce two different types of spatial distributions of forces, detected between the particles accompanied by hyperbolic hedgehog defects. These force distributions lead to specific particle arrangements, which are both stabilized by the balance of the orientational stress field of nematics. On the basis of these results, we propose novel artificial construction for multiparticle regular arrangements.

