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Immunosuppressants.

J W Marsh1, K L Vehe, H M White

  • 1Washington University School of Medicine, St. Louis, Missouri.

Gastroenterology Clinics of North America
|September 1, 1992
PubMed
Summary
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This review covers immunosuppressants like cyclosporine and corticosteroids for gastrointestinal and liver conditions. It details their use, complications, and guidelines in organ transplantation and digestive disorders.

Area of Science:

  • Gastroenterology and Hepatology
  • Transplant Medicine
  • Clinical Pharmacology

Background:

  • Immunosuppressant agents are crucial for managing organ rejection and autoimmune diseases.
  • Understanding the pharmacology and clinical applications of these drugs in the GI tract and liver is essential.
  • Various immunosuppressants have distinct roles and potential complications.

Purpose of the Study:

  • To review the role and pharmacology of key immunosuppressant agents in the gastrointestinal tract and liver.
  • To present guidelines for the use and management of complications in liver, pancreas, and small bowel transplantations.
  • To describe data on immunosuppressant use in gastrointestinal and hepatic disorders.

Main Methods:

  • Comprehensive literature review of immunosuppressant agents.

Related Experiment Videos

  • Analysis of clinical data, including controlled and uncontrolled studies.
  • Synthesis of guidelines for transplantation and management of GI/hepatic disorders.

    • Main Results:

    • Detailed pharmacology and clinical roles of cyclosporine, corticosteroids, OKT3, antithymocyte globulin, azathioprine, methotrexate, and FK506.
    • Established guidelines for immunosuppressant use in liver, pancreas, and small bowel transplantation.
    • Summarized evidence for immunosuppressants in managing gastrointestinal and hepatic disorders.

    Conclusions:

    • Immunosuppressants are vital in transplantation and managing GI/hepatic diseases.
    • Adherence to guidelines and awareness of complications are critical for patient outcomes.
    • Further research can optimize immunosuppressive strategies in gastroenterology and hepatology.