Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Basophil degranulation control.

B Hadjaj1, Y Cherruault, J Sainte Laudy

  • 1Université Paris 6, Medimat, France.

International Journal of Bio-Medical Computing
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pre-lethal anaphylaxis to carboxymethylcellulose confirmed by identification of specific IgE--review of the literature.

European annals of allergy and clinical immunology·2010
Same author

Diagnostic tests based on human basophils: more potentials and perspectives than pitfalls. II. Technical issues.

Journal of investigational allergology & clinical immunology·2008
Same author

[Investigation of allergic reactions to platinum salts].

Revue des maladies respiratoires·2007
Same author

[Evolution of the immunobiologic diagnosis in allergy].

Allergie et immunologie·1996
Same author

DIVANU: a new method for global optimization.

International journal of bio-medical computing·1995
Same author

A new method for global optimization in two dimensions.

International journal of bio-medical computing·1995

This study models how high dilutions inhibit human basophil degranulation. Dynamic programming solved an optimal control problem linked to antigen concentration in a non-linear model.

Area of Science:

  • Immunology
  • Computational Biology
  • Pharmacology

Background:

  • Basophil degranulation plays a key role in allergic responses.
  • High dilutions are used in some alternative medicine practices, but their mechanisms are debated.
  • Understanding cellular inhibition mechanisms is crucial for developing new therapeutic strategies.

Purpose of the Study:

  • To develop a global simulation model for human basophil degranulation inhibition by high dilutions.
  • To investigate an optimal control problem associated with antigen concentration.
  • To apply computational methods for analyzing biological control systems.

Main Methods:

  • A global simulation model was developed to describe basophil degranulation.
  • An optimal control problem was formulated for a non-linear compartmental model.

Related Experiment Videos

  • Dynamic programming was employed to solve the control problem related to antigen concentration.

    • Main Results:

    • The study presents a simulation model for high-dilution inhibition of basophil degranulation.
    • An optimal control strategy was identified concerning antigen concentration.
    • The dynamic programming approach successfully addressed the control problem within the non-linear model.

    Conclusions:

    • The developed model provides a framework for understanding high-dilution effects on basophils.
    • Optimal control principles can be applied to biological systems involving antigen-antibody interactions.
    • Computational modeling and dynamic programming offer powerful tools for investigating complex immunological processes.