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Updated: Aug 24, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Amniotic fluid embolism with haemostasis complications: primary fibrinogenolysis or disseminated intravascular
C Biron-Andréani1, E Morau, J-F Schved
1Laboratoire d'Hématologie, Centre Hospitalier Universitaire, Montpellier, France. c-biron@chu-montpellier.fr
Abstract:
Amniotic fluid embolism (AFE) is characterized by the passage of amniotic fluid (AF) into the maternal circulation during or just after childbirth. AFE is a rare disorder occurring in 1/8,000 to 1/80,000 deliveries but with a maternal morbidity ranging from 26% in a recent report to 86% in earlier ones. In patients who survive, AFE may affect coagulation resulting in severe bleeding. While disseminated intravascular coagulation (DIC) is usually seen in such cases, we reported a case of AFE in which the hemostatic abnormalities were compatible with primary fibrinogenolysis rather than with DIC.
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