Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hsp90 invades the outside.

Didier Picard

    Nature Cell Biology
    |June 2, 2004
    PubMed
    Summary
    This summary is machine-generated.

    The molecular chaperone Hsp90 aids cancer cell invasion by promoting the maturation of extracellular metalloprotease MMP2. This discovery reveals a novel extracellular role for Hsp90 beyond its known intracellular functions.

    Related Experiment Videos

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Retraction notice to "17β-Estradiol, Genistein, and 4-Hydroxytamoxifen Induce the Proliferation of Thyroid Cancer Cells through the G Protein-Coupled Receptor GPR30" [Mol Pharmacol 70 (2006) 1414-1423].

    Molecular pharmacology·2025
    Same author

    Correction: Hsf1 and the molecular chaperone Hsp90 support a 'rewiring stress response' leading to an adaptive cell size increase in chronic stress.

    eLife·2025
    Same author

    A white paper from the FEBS Education and Training Conference: challenges, opportunities, and action plans for transforming molecular life sciences education.

    FEBS open bio·2024
    Same author

    Hsf1 and the molecular chaperone Hsp90 support a 'rewiring stress response' leading to an adaptive cell size increase in chronic stress.

    eLife·2023
    Same author

    Proteomic Analyses of the G Protein-Coupled Estrogen Receptor GPER1 Reveal Constitutive Links to Endoplasmic Reticulum, Glycosylation, Trafficking, and Calcium Signaling.

    Cells·2023
    Same author

    CRISPR-Cas9 screen reveals a role of purine synthesis for estrogen receptor α activity and tamoxifen resistance of breast cancer cells.

    Science advances·2023

    Area of Science:

    • Molecular biology
    • Cancer research
    • Cell biology

    Background:

    • Metalloproteases, such as MMP2, are crucial for cancer cell invasion.
    • Hsp90 is a cytosolic molecular chaperone with diverse cellular roles.

    Discussion:

    • This study reveals that Hsp90 directly influences the extracellular metalloprotease MMP2.
    • Hsp90's role in MMP2 maturation suggests a mechanism for enhanced cancer cell invasiveness.
    • This finding expands the known functions of Hsp90 to extracellular processes.

    Key Insights:

    • Cytosolic Hsp90 promotes the maturation of extracellular metalloprotease MMP2.
    • Hsp90 facilitates cancer cell invasion through MMP2 pathway.
    • Hsp90 functions extracellularly to regulate MMP2 activity.

    Outlook:

    • Further research can explore therapeutic strategies targeting the Hsp90-MMP2 interaction to inhibit cancer metastasis.
    • Investigating other extracellular roles of Hsp90 may uncover new therapeutic targets.