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Correlated measures in longitudinal analysis of daily drug use patterns in a general intensive care unit
Joost J Stolker1, Eibert R Heerdink, Frans G Zitman
1Altrecht Institute for Mental Health Care, Den Dolder, The Netherlands. j.stolker@altrecht.nl
Purpose:
The objective of the present study is to compare two different study designs (with and without corrections for correlated measures) to identify possible determinants of psychotropic drug use in an intensive care unit (ICU).
Methods:
In a logistic regression analysis, odds ratios (OR) were calculated for days in which patients were exposed to psychotropics compared with non-exposed days. In order to adjust for correlated measures, logistic regression with a logistic binomial model was applied.
Results:
We found that adjustment for correlated measures did not result in major changes in the OR. However, with more observations per patient parameter, adjustment for correlation has greater effect.
Conclusions:
Adjustment for correlated measures may be useful in longitudinal drug analyses.
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