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Related Experiment Videos

MR-trackable intramyocardial injection catheter.

P V Karmarkar1, D L Kraitchman, I Izbudak

  • 1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21025, USA. pkarmar@mri.jhu.edu

Magnetic Resonance in Medicine
|June 2, 2004
PubMed
Summary

A novel MRI-guided catheter precisely delivers cellular therapies to heart attack damage. This steerable intramyocardial injection system enables targeted treatment, improving outcomes for myocardial infarction patients.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Medical Imaging

Background:

  • Cellular therapies show promise for preventing adverse left ventricular remodeling after myocardial infarction.
  • Magnetic Resonance Imaging (MRI) effectively distinguishes infarcted from healthy heart tissue.
  • Precise targeting of therapeutics within the infarct is crucial for effective cellular delivery.

Purpose of the Study:

  • To develop and evaluate a steerable intramyocardial injection catheter actively tracked under MRI.
  • To assess the feasibility of MR-guided catheterization and targeted delivery in myocardial infarction models.

Main Methods:

  • A novel catheter with a loopless RF antenna receiver coil for active MRI tracking was designed.
  • Feasibility studies were conducted in canine and porcine myocardial infarction models.

Related Experiment Videos

  • Real-time MRI guided catheterization via a carotid artery approach, with intramyocardial injection confirmed by imaging and histology.

    • Main Results:

    • The catheter's distal tip was clearly visualized under MRI, enabling precise navigation.
    • Successful intramyocardial injection of contrast agent and dye was achieved in infarct regions.
    • A pilot study demonstrated the system's utility for delivering magnetically labeled stem cells.

    Conclusions:

    • The developed MR-guided steerable catheter allows for precise, real-time intramyocardial delivery of cellular agents.
    • This technology holds significant potential for targeted therapy in post-myocardial infarction treatment.
    • Active MRI tracking enhances the accuracy and safety of cardiac cellular delivery procedures.