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Ewing sarcoma: favourable results with combined modality therapy and conservative use of radiotherapy
George Zogopoulos1, Lindsay Teskey, Lillian Sung
1Division of Hematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.
Background:
At the Hospital for Sick Children (HSC), we have treated Ewing sarcoma (ES) with multi-agent chemotherapy, surgery and conservative use of radiotherapy for local control. Our objective was to describe the outcome and prognostic factors associated with this strategy.
Procedure:
We performed a retrospective chart review of children diagnosed with ES at HSC from Feb 1984 to June 1999.
Results:
Seventy-two evaluable children were identified. All received chemotherapy. Local control administered was surgery (n = 37), radiation (n = 23), both (n = 10) or neither (n = 2). The 7-year EFS was 66.4%. Recurrence occurred in 23 patients, 7 locally and 16 distantly. Better EFS was associated with male gender (78.5% vs. 52.1%; P = 0.007), localised disease (77.0% vs. 39.4%; P = 0.0004), extremity primary (88.2% vs. 52.8%; P = 0.005) and non-pelvic primary (75.7% vs. 18.2%; P < 0.0001).
Conclusions:
Favourable outcomes were seen for patients treated with multi-agent chemotherapy, surgery and conservative use of radiotherapy. Metastatic disease rather than local control was the major cause of failure.