Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD19 negative precursor B acute lymphoblastic leukemia presenting with hypercalcemia.

Iyad Sultan1, Jacqueline M Kraveka, John Lazarchick

  • 1Pediatric Hematology Oncology, Medical University of South Carolina, Charleston, 29425, USA.

Pediatric Blood & Cancer
|June 2, 2004
PubMed
Summary

This case study details a 9-month-old infant with hypercalcemia and bone lesions, diagnosed with precursor B acute lymphoblastic leukemia (ALL). Immunoglobulin gene rearrangement confirmed the diagnosis, leading to effective chemotherapy and resolution of symptoms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic Value of Pre-Treatment Systemic Inflammatory Markers in Pediatric Unilateral Wilms Tumor.

Cancers·2026
Same author

Secondary hemophagocytic lymphohistiocytosis in pediatric patients: a single-center experience.

Frontiers in pediatrics·2026
Same author

Utilizing [<sup>18</sup>F]-FDG PET/CT Imaging for Enhanced Staging and Treatment Decisions in Pediatric Rhabdomyosarcoma.

Cancers·2026
Same author

Beyond the 5-Year Window: Late-Onset Ocular Morbidity and a Proposed 10-Year Functional Survivorship Protocol for Pediatric Orbital Rhabdomyosarcoma.

Cancers·2026
Same author

Ruptured Wilms Tumor: Clinical Features, Diagnostic Challenges, and Survival Outcomes.

Current oncology (Toronto, Ont.)·2026
Same author

Exploring Two Decades of Cancer Trends in Adolescents and Young Adults: Insights From a Resource-Restricted Country.

World journal of oncology·2026

Area of Science:

  • Pediatric Oncology
  • Hematology
  • Molecular Diagnostics

Background:

  • Infantile acute lymphoblastic leukemia (ALL) can present with unusual clinical features.
  • Hypercalcemia and lytic bone lesions are rare but significant presenting signs in pediatric ALL.
  • Accurate immunophenotyping and molecular studies are crucial for diagnosing atypical ALL cases.

Observation:

  • A 9-month-old infant presented with hypercalcemia and lytic bone lesions.
  • Bone marrow examination revealed a small round blue cell infiltrate with an atypical immunophenotype (dim CD45, HLA-DR, CD10+, CD19-, CD20-, CD79a-, CD34-).
  • Initial supportive treatment for hypercalcemia was insufficient, with recurrent episodes.

Findings:

  • Southern blotting confirmed clonal rearrangement of the immunoglobulin heavy chain (IgH) gene.

Related Experiment Videos

  • This molecular finding established the diagnosis of precursor B acute lymphoblastic leukemia (ALL).
  • Treatment with an infantile ALL chemotherapeutic regimen led to complete resolution of hypercalcemia.

    • Implications:

    • Immunoglobulin gene rearrangement is a valuable tool for diagnosing atypical cases of acute lymphoblastic leukemia.
    • Early and accurate diagnosis of ALL is critical for effective treatment and management of presenting complications like hypercalcemia.
    • This case underscores the importance of integrating molecular diagnostics in pediatric hematologic malignancies.