Related Experiment Video
Updated: Aug 24, 2026
Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis
Published on: October 13, 2023
Human chorionic gonadotropin-beta in endometrium cancer tissue
E Nowak-Markwitz1, A Jankowska, A Szczerba
1Division of Obstetrics and Gynecology, Department of Gynecologic Oncology, Karol Marcinkowski University of Medical Science, Poznań, Poland.
Purpose:
Determination of the correlation between expression of human chorionic gonadotropin mRNA and serum free hCGb immunoreactivity in endometrial cancer tissue.
Methods:
The study included 56 patients with endometrial carcinoma Stages IB-III. The expression of mRNA hCGbeta was determined by the RT PCR method in 18 cases of cancerous and precancerous tissues. The serum-free hCGbeta immunoreactivity was analyzed by sequential immunometric assay in all patients.
Results:
In 15 study specimens of endometrial carcinoma tissue mRNA of hCGbeta was detected. Also in endometrial atypical hyperplasia, expression of hCGbeta was found. Noncancerous tissue demonstrated lack of the hCGbeta transcript. The serum immunoreactivity in the endometrial cancer group was detectable in 86% of cases. There were no significant differences between FIGO stages and grading.
Conclusion:
The results of the present study confirmed the presence of active genes of hCGbeta in endometrial cancer tissue, even in precancerous changes. The serum immunoreactivity of free hCGbeta is a less common feature and is not linked with tumor stage or grade in endometrial cancer patients.
