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[Preparation of all-trans retinoic acid mixed micelles injection]
1Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China. kfzl@hotmail.com
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|June 3, 2004
Abstract
Aim:
To increase the solubility and bioavailability of all-trans retinoic acid (ATRA).
Methods:
Using the principle of lecthin/bile salt mixed micelle to prepared ATRA injection. The best formulation was obtained by the turbidity and three-phase figure.
Results:
ATRA mixed micelles injection is stable. The average size of the mixed micelle is 17.8 nm, poly. index 0.495, zeta potential -16.5 mV.
Conclusion:
The method can be used to prepare the stable injection.
