Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Preanalytic aspects in postmortem toxicology.

G Skopp1

  • 1Institut für Rechtsmedizin und Verkehrsmedizin, Ruprecht-Karls-Universität, Vossstr. 2, 69115 Heidelberg, Germany. gisela_skopp@med.uni-heidelberg.de

Forensic Science International
|June 3, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Findings of illicit drugs in hair of children at different ages.

International journal of legal medicine·2021
Same author

Concentration distribution of more than 100 drugs and metabolites in forensic hair samples.

International journal of legal medicine·2020
Same author

Systemic inflammatory response due to chloroform intoxication--an uncommon complication.

International journal of legal medicine·2015
Same author

Comparison of direct and indirect alcohol markers with PEth in blood and urine in alcohol dependent inpatients during detoxication.

International journal of legal medicine·2013
Same author

Driving performance in adults with ADHD: results from a randomized, waiting list controlled trial with atomoxetine.

European psychiatry : the journal of the Association of European Psychiatrists·2012
Same author

A randomized, waiting list-controlled 12-week trial of atomoxetine in adults with ADHD.

Pharmacopsychiatry·2011

Postmortem toxicology relies heavily on specimen quality, facing challenges like degradation and variable sample integrity. Understanding preanalytic factors is crucial for accurate drug and poison analysis in forensic investigations.

Area of Science:

  • Forensic Toxicology
  • Analytical Chemistry
  • Postmortem Medicine

Background:

  • The preanalytic phase significantly impacts the reliability of toxicological results.
  • Postmortem specimen collection presents unique challenges due to sample quantity and variability.
  • Autolytic and putrefactive changes can alter drug and poison concentrations in specimens.

Purpose of the Study:

  • To provide an overview of specimen selection and collection for postmortem toxicology.
  • To discuss factors affecting drug and poison stability in postmortem samples.
  • To highlight the importance of preanalytic considerations for accurate forensic analysis.

Main Methods:

  • Review of literature on postmortem specimen collection and preservation.
  • Discussion of drug degradation and formation during putrefaction.

Related Experiment Videos

  • Analysis of factors influencing analyte concentrations, including fixation and embalmment.

    • Main Results:

    • Various specimens, including alternative ones, can provide crucial toxicological information.
    • Postmortem changes (autolysis, putrefaction, diffusion) and preservation methods (formalin, embalmment) significantly alter analyte levels.
    • Knowledge of degradation mechanisms aids in identifying target substances and breakdown products.

    Conclusions:

    • Careful consideration of preanalytic factors is essential for assessing postmortem sample quality.
    • Standardized protocols for postmortem sampling in suspected poisonings are lacking but necessary.
    • Understanding analyte stability and degradation is key to reliable forensic toxicological interpretation.