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Related Experiment Videos

Decreased CD14+CCR2+ monocytes in active multiple sclerosis.

Hideto Nakajima1, Masakazu Sugino, Fumiharu Kimura

  • 1First Department of Internal Medicine, Osaka Medical College, 2-7 Daigakumachi, Takatsuki City, Osaka 569-8686, Japan. in1045@poh.osaka-med.ac.jp

Neuroscience Letters
|June 3, 2004
PubMed
Summary

In active multiple sclerosis (MS), the Th1/Th2 immune balance shifts, with decreased expression of CCR2 and CD14 on monocytes. This suggests monocytes play a role in MS remission.

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Area of Science:

  • Immunology
  • Neuroscience

Background:

  • Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
  • Immune cell dysregulation, particularly involving T-helper cells and monocytes, is implicated in MS pathogenesis.

Purpose of the Study:

  • To investigate the expression of CCR2 on blood monocytes and the Th1/Th2 balance in patients with active MS.
  • To explore the correlation between monocyte markers and the Th1/Th2 ratio in MS.

Main Methods:

  • Three-color flow cytometry was used to quantify CD4+CXCR3+ (Th1) cells, CD4+CCR4+ (Th2) cells, and CD14+CCR2+ monocytes.
  • Analysis was performed on 15 patients with active MS and compared to healthy controls.

Main Results:

  • The Th1/Th2 ratio (CD4+CXCR3+/CD4+CCR4+) was significantly elevated in active MS patients compared to controls.

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  • Expression of CCR2 and CD14 on monocytes was markedly decreased in MS patients.
  • A significant negative correlation was observed between the Th1/Th2 ratio and monocyte CCR2/CD14 expression.

    • Conclusions:

    • The Th1/Th2 imbalance and reduced monocyte CCR2/CD14 expression are characteristic of active MS.
    • CD14+CCR2+ blood monocytes may be crucial in the transition from active MS to disease remission.