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Kingella kingae: from medical rarity to an emerging paediatric pathogen

Pablo Yagupsky1

  • 1Clinical Microbiology Laboratories, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel. yagupsky@bgumail.bgu.ac.il

The Lancet. Infectious Diseases
|June 3, 2004
PubMed

Insights

Kingella kingae causes invasive infections in children, often presenting subtly. Optimizing its recovery through blood culture vials is crucial for diagnosis and treatment.

Area of Science:

  • Pediatric Infectious Diseases
  • Clinical Microbiology

Background:

  • Kingella kingae is an emerging pathogen causing invasive infections in young children.
  • Commonly presents as septic arthritis, osteomyelitis, and bacteremia, often preceded by stomatitis or upper respiratory symptoms.

Purpose of the Study:

  • To highlight the increasing prevalence and clinical significance of invasive Kingella kingae infections in pediatric populations.
  • To emphasize diagnostic considerations and optimal recovery methods for Kingella kingae.

Main Methods:

  • Review of clinical presentations and laboratory findings associated with invasive Kingella kingae infections.
  • Discussion of microbiological techniques for isolating Kingella kingae, particularly from sterile sites.

Main Results:

  • Invasive Kingella kingae disease often has subtle clinical signs and normal initial laboratory tests.
  • The organism is part of the pharyngeal flora and transmitted child-to-child.
  • Kingella kingae is susceptible to common antibiotics, with most infections having a benign course, except for endocarditis.

Conclusions:

  • Clinicians and microbiologists must be aware of Kingella kingae's fastidious nature for accurate diagnosis.
  • Inoculating synovial fluid into blood culture vials significantly improves Kingella kingae recovery rates.

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