Related Experiment Video

Updated: May 10, 2026

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
09:31

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Defective core-apoptosis signalling in diffuse malignant pleural mesothelioma: opportunities for effective drug

Dean A Fennell1, Robin M Rudd

  • 1Department of Medical Oncology, Lung Cancer and Mesothelioma Research Group, St Bartholomew's Hospital, West Smithfield, London, UK. d.a.fennell@qmul.ac.uk

The Lancet. Oncology
|June 3, 2004
PubMed

Insights

Diffuse pleural mesothelioma has poor survival due to ineffective treatments. Recent advances in apoptosis biology offer new therapeutic strategies to improve patient outcomes for this aggressive cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Diffuse pleural mesothelioma is an aggressive cancer with limited effective treatment options.
  • Poor patient survival is linked to a lack of understanding regarding mesothelioma's apoptosis-resistant phenotype.
  • The incidence of mesothelioma is projected to increase over the next two decades.

Purpose of the Study:

  • To review recent advancements in the understanding of mesothelioma apoptosis biology.
  • To explore emerging therapeutic drug development strategies targeting mesothelioma.
  • To discuss the potential impact of these developments on patient survival and disease natural history.

Main Methods:

  • Literature review of recent research on mesothelioma biology and apoptosis.
  • Analysis of emerging therapeutic strategies and drug development in mesothelioma.
  • Synthesis of findings to discuss clinical implications.

Main Results:

  • Progress is being made in understanding the molecular mechanisms of apoptosis resistance in mesothelioma.
  • Novel therapeutic strategies are being developed based on these biological insights.
  • These emerging therapies hold promise for improving survival rates.

Conclusions:

  • Understanding mesothelioma's specific apoptosis biology is crucial for developing effective treatments.
  • Emerging therapeutic strategies have the potential to significantly alter the disease's natural history.
  • Future research and drug development in this area are critical for improving outcomes in mesothelioma patients.

More Related Videos

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Apoptosis01:30

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...