Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nursing Ethical Principles II

Nursing Ethical Principles II

Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's cancer...

Nurses' Legal Responsibilities I

Nurses' Legal Responsibilities I

In healthcare, informed consent is a crucial process that involves thoroughly communicating medical treatment options to patients, including benefits, risks, potential side effects, and alternatives. This process enables patients to make well-informed decisions about their care, ensuring they understand the implications of their choices before consenting to or refusing treatment.
The legal responsibilities of a nurse regarding informed consent include the following:

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...

Pharmacokinetics in Pediatric Patients: Drug Distribution

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

Pharmacokinetics in Pediatric Patients: Drug Metabolism

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...

Pharmacokinetics in Pediatric Patients: Drug Excretion

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Health migration and care disparities.

Pediatric blood & cancer·2011

Same author

Seeking treatment abroad. Challenge of migrating patients.

BMJ (Clinical research ed.)·2010

Same author

Dreaming about the homeland: nostalgia of immigrant children with cancer.

Pediatric blood & cancer·2010

Same author

Back home.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2010

Same author

Translational research in hormone-related cancer.

Annals of the New York Academy of Sciences·2009

Same author

Health emigration: a challenge in paediatric oncology.

Journal of child health care : for professionals working with children in the hospital and community·2008

Search research articles

Related Experiment Video

Updated: May 11, 2026

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

From informed consent to shared consent: a developing process in paediatric oncology.

Luisa M Massimo¹, Thomas J Wiley, Ezio F Casari

¹Paediatric Haematology and Oncology Unit, G Gaslini Scientific Children's Hospital, Genoa, Italy. luisamassimo@ospedale-gaslini.ge.it

The Lancet. Oncology

|June 3, 2004

Summary

Informed consent for pediatric cancer treatment is challenging. A shared-consent model, using problem-based learning, improves communication and understanding for children and parents.

Keywords:

Biomedical and Behavioral Research Professional Patient Relationship

More Related Videos

Working with Human Tissues for Translational Cancer Research

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research

Published on: July 31, 2017

Related Experiment Videos

Last Updated: May 11, 2026

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

Working with Human Tissues for Translational Cancer Research

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research

Published on: July 31, 2017

Area of Science:

Pediatric Oncology
Bioethics
Medical Education

Background:

Limited research exists on informed consent in pediatric cancer care.
Parents find the informed-consent process helpful yet confusing, especially regarding randomization.
Understanding bioethical and psychological principles is crucial for effective consent.

Purpose of the Study:

To discuss clinical challenges in informed consent for pediatric cancer treatment and research.
To propose a shared-consent model to improve the process.
To enhance communication and information delivery to pediatric patients.

Main Methods:

Discussing clinical problems in informed consent for pediatric oncology.
Proposing a negotiated shared-consent process guided by problem-based learning.
Recommending specific communication and ethics training for medical professionals.

Main Results:

The proposed shared-consent model facilitates honest and appropriate information exchange.
Easy-to-understand dialogues enhance comprehension for children and adolescents.
The model addresses the complexities of randomization and treatment decisions.

Conclusions:

A negotiated shared-consent process is recommended for pediatric cancer care.
Problem-based learning can guide effective informed consent discussions.
Training medical professionals in communication, ethics, and relational behavior is essential.