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Updated: Aug 24, 2026

In Utero Electroporation of Multiaddressable Genome-Integrating Color (MAGIC) Markers to Individualize Cortical Mouse Astrocytes
Published on: May 21, 2020
A complex rearrangement of chromosome 7 in human astrocytoma
Anjan Misra1, Malgorzata Pellarin, Joan R Shapiro
1Division of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA. amisra@cc.ucsf.edu
Abstract:
Chromosome 7 is a frequent site of cytogenetic aberrations in human astrocytomas. One region that is often targeted in human astrocytomas is on 7p. The U251 human glioblastoma cell line has a region of gain of genetic material on 7p similar to that seen in human astrocytomas. We used several cytogenetic techniques to study chromosome 7 in U251 cells and identified a complex rearrangement that accounts for gain of chromosome 7 genetic material in the cell line. The characteristic rearrangement suggests a mechanism leading to 7p gain in primary grade IV astrocytomas.
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