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Analysis of meconium for cocaine in neonates
S P Browne1, I R Tebbett, C M Moore
1Department of Pharmacodynamics, University of Illinois, Chicago 60680.
Journal of Chromatography
|March 13, 1992
Abstract:
A solid-phase extraction method was developed for the extraction of first-day meconium samples from premature infants of cocaine-dependent mothers. Extracts were analysed by high-performance liquid chromatography and gas chromatography-mass spectrometry for cocaine and its metabolites. Control stools showed no drug. Meconium from cocaine-dependent mothers showed cocaine in the range 0.1-0.78 micrograms/g. Benzoylecgonine, ecgonine and ecognine methyl ester were not present in the samples, which suggests that the metabolism of cocaine in the premature neonate is limited.