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Histologic changes after vertebroplasty.

J J Verlaan1, F C Oner, P J Slootweg

  • 1University Medical Center Utrecht, Utrecht, The Netherlands. jj.verlaan@wxs.nl

The Journal of Bone and Joint Surgery. American Volume
|June 3, 2004
PubMed
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Both polymethylmethacrylate and calcium phosphate cements are safe for vertebroplasty. Studies show no disc or end-plate degeneration with either cement, indicating suitability for spinal lesion treatment.

Area of Science:

  • Spinal surgery
  • Biomaterials science
  • Orthopedic research

Background:

  • Vertebroplasty using polymethylmethacrylate cement is increasingly common for spinal lesions.
  • Potential side effects of polymethylmethacrylate cement on vertebral bodies require investigation.
  • Histologic and radiographic analysis is needed to compare polymethylmethacrylate cement with calcium phosphate cement.

Purpose of the Study:

  • To compare the histologic and radiographic effects of polymethylmethacrylate cement versus calcium phosphate cement on goat spine tissues.
  • To evaluate the impact of simulated end-plate defects on disc and end-plate degeneration.

Main Methods:

  • Twenty-four goats underwent bilateral transpedicular vertebroplasty with either calcium phosphate or polymethylmethacrylate cement.

Related Experiment Videos

  • Procedures included variations with and without simulated end-plate defects.
  • Histologic and radiographic analyses assessed disc, end-plate, and surrounding tissue integrity.

    • Main Results:

    • No disc or end-plate degeneration was observed in any treatment group.
    • Disc height remained stable post-procedure across all groups.
    • Mild inflammation occurred in polymethylmethacrylate groups, but not with calcium phosphate cement.

    Conclusions:

    • Both calcium phosphate cement and polymethylmethacrylate cement demonstrate adequate biological behavior as bone-void fillers in the vertebral body.
    • Neither cement type induced significant disc or end-plate degeneration in the goat model.