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Updated: Aug 24, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Assessment of heat tolerance for post exertional heat stroke individuals
Daniel S Moran1, Yuval Heled, Lawrence Still
1Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer 52621, Israel. dmoran@sheba.health.gov.il
Background:
The aim of this study was to evaluate the heat tolerance test, which was performed by individuals with high risk for heat injuries, for exposure duration and climatic conditions.
Material/Methods:
Nineteen young (19+/-1 yr) post heat stroke males performed 2 separate tolerance tests consisting of identical treadmill walking (5km.h-1, 2% grade) for 120 min during hot (40 degrees C, 40%RH) and comfort (20 degrees C, 50%RH) climate conditions. Physiological monitoring included rectal temperature (Tre), heart rate (HR), skin temperature and sweat rate (msw). Concomitantly, strain evaluation was assessed by the physiological strain index (PSI) and the cumulative heat strain index (CHSI).
Results:
14 subjects were categorized as heat tolerant (HT) and 5 subjects as heat intolerant (HI). The comfort tolerance test was found as irrelevant for heat intolerance assessment. PSI after 60 min (PSI60) was unable to predict PSI after 120 min (PSI120) whereas there was not a high enough correlation between CHSI60 and CHSI120.
Conclusions:
It was concluded that tolerance to heat must be tested during heat stress and the test duration cannot be shorter than 120 min.
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Exercise Stress Test
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Decreased Body Temperature
Factors Affecting Body Temperature
Factors may include:

