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Unimod: Protein modifications for mass spectrometry.

David M Creasy1, John S Cottrell

  • 1Matrix Science Ltd., London, UK.

Proteomics
|June 3, 2004
PubMed
Summary

Unimod is a protein modification database for mass spectrometry. It provides accurate mass difference values for natural and artificial modifications, aiding protein identification and sequencing.

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Area of Science:

  • Biochemistry
  • Analytical Chemistry
  • Proteomics

Background:

  • Mass spectrometry is crucial for protein analysis.
  • Accurate mass data is essential for identifying and sequencing proteins.
  • Databases of protein modifications enhance mass spectrometry workflows.

Purpose of the Study:

  • To introduce Unimod, a comprehensive database of protein modifications.
  • To provide accurate, verifiable mass values for modifications.
  • To support mass spectrometry applications like protein identification and de novo sequencing.

Main Methods:

  • Compiling data on natural and artificial protein modifications.
  • Calculating mass differences based on elemental compositions.
  • Ensuring accuracy and verifiability of all data entries.

Main Results:

  • Unimod contains a curated collection of protein modification masses.
  • Values are derived from precise elemental compositions.
  • The database facilitates accurate mass spectrometry data interpretation.

Conclusions:

  • Unimod serves as a valuable resource for proteomics research.
  • It improves the reliability of protein identification and sequencing using mass spectrometry.
  • The database supports advancements in understanding protein function and regulation.

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