Electroencephalographical effects of sarpogrelate hydrochloride versus ticlopidine hydrochloride in elderly patients...

Area of Science:

• Neurology
• Pharmacology
• Geriatrics

Background:

• Peripheral circulatory disorders affect cerebrovascular function, particularly in elderly populations.
• Serotonin plays a role in pathological processes associated with these disorders.
• Subclinical arteriosclerosis is common in elderly patients and can impact vascular health.

Purpose of the Study:

• To evaluate the efficacy of sarpogrelate, a selective 5-hydroxytryptamine-2-serotonergic receptor antagonist, on cerebrovascular function and mean blood pressure (mBP).
• To compare the effects of sarpogrelate with ticlopidine in elderly patients (> 60 years old) with peripheral circulatory disorders.

Main Methods:

• A 2-year prospective study involving elderly patients with peripheral circulatory disorders.
• Electroencephalogram (EEG) and mBP measurements were recorded before and after treatment.
• Patients were treated with either sarpogrelate (n=31) or ticlopidine (n=43).

Main Results:

• Sarpogrelate significantly decreased the percentage of slow waves (%slow) and increased alpha wave percentage (%alpha) in the posterior brain area.
• Sarpogrelate showed a significantly higher delta alpha value compared to ticlopidine in the posterior area.
• Ticlopidine did not produce significant EEG changes in the whole brain or anterior areas.

Conclusions:

• Sarpogrelate hydrochloride demonstrates efficacy in suppressing serotonin-induced pathological processes in peripheral circulatory disorders.
• Sarpogrelate may be a recommended anti-platelet agent for elderly patients, including those with subclinical arteriosclerosis.
• The drug positively influences cerebrovascular function, particularly in the posterior brain regions.