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Related Experiment Videos

Choroid plexus papillomas: a single institutional experience.

Sunil Krishnan1, Paul D Brown, Bernd W Scheithauer

  • 1Division of Radiation Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA.

Journal of Neuro-Oncology
|June 4, 2004
PubMed
Summary
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Surgical resection is the primary treatment for choroid plexus papillomas (CPPs). Gross total resection offers better local control than subtotal resection, though reoperations for recurrence after subtotal resection are infrequent.

Area of Science:

  • Neurosurgery
  • Pediatric Neurosurgery
  • Neuropathology

Background:

  • Choroid plexus papillomas (CPPs) are rare tumors.
  • Understanding long-term outcomes after resection is crucial for treatment planning.

Purpose of the Study:

  • To evaluate the long-term outcomes of surgically resected choroid plexus papillomas.
  • To compare the efficacy of gross total resection (GTR) versus subtotal resection (STR).

Main Methods:

  • Retrospective review of 41 patients with CPPs treated between 1974 and 2000.
  • Analysis of tumor location, extent of resection (GTR vs. STR), and follow-up data.
  • Statistical comparison of outcomes based on resection type.

Main Results:

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  • Five-year local control, distant brain control, and overall survival rates were 84%, 92%, and 97%, respectively.
  • GTR demonstrated significantly higher 5-year local control (100% vs. 68%; P=0.04) compared to STR.
  • Reoperations for recurrence were needed in only 50% of patients after initial STR; radiation therapy showed no clear benefit.

    • Conclusions:

    • Surgical resection remains the gold standard for CPP treatment.
    • While GTR improves local control, STR may be sufficient as reoperations are infrequent.
    • Radiation therapy does not appear to enhance outcomes after initial STR, and outcomes for STR at first relapse are poor.