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Clinical characteristics of subjects with the Brugada-type electrocardiogram:

Kiyotaka Matsuo1, Masazumi Akahoshi, Eiji Nakashima

  • 1Department of Clinical Studies, Radiation Effects Research Foundation, Nagasaki, Japan.

Journal of Cardiovascular Electrophysiology
|June 4, 2004
PubMed

Insights

Japanese men with Brugada-type electrocardiograms (ECG) have a lower body mass index (BMI) than controls. This finding suggests a potential link between lower BMI and the underlying mechanisms of Brugada-type ECG.

Area of Science:

  • Cardiology
  • Clinical Electrophysiology

Background:

  • Brugada-type electrocardiogram (ECG) is characterized by ST segment elevation in right precordial leads.
  • While prevalent in Japanese men, clinical features remain under-researched.

Purpose of the Study:

  • To investigate the clinical characteristics of Japanese men diagnosed with Brugada-type ECG.

Main Methods:

  • Retrospective analysis of 3,374 men from Nagasaki, Japan, followed from 1958-2001.
  • Comparison of clinical data between 34 Brugada-type ECG cases and age-matched male controls.

Main Results:

  • Brugada-type ECG cases exhibited significantly lower body mass index (BMI) at diagnosis compared to controls (20.2 vs 21.8 kg/m²).
  • Lower BMI trend persisted in cases throughout an 8-year observation period around diagnosis.
  • Pulse rate was lower in cases, but this significance diminished after adjusting for BMI or body weight.

Conclusions:

  • Lower BMI is a distinct clinical characteristic associated with Brugada-type ECG in Japanese men.
  • This association provides a potential avenue for exploring the basic mechanisms underlying Brugada-type ECG.
Abstract

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