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Updated: Aug 11, 2026
Analysis of Physiologic E-Selectin-Mediated Leukocyte Rolling on Microvascular Endothelium
Published on: February 10, 2009
[P-selectin as endothelial reactivity marker in patients with pre-eclampsia]
José Daniel Salazar-Exaire1, Ruth Iliana Reyes-Martínez, Raúl González-Alvarez
1Unidad de Investigación Hospital de Especialidades, México.
Introduction:
Pre-eclampsia affects 5% of all pregnancies. The physiopathologic hallmark is altered endothelium function and platelet activation. Selectins are molecules involved with the regulation between these systems, P-selectin is a molecule expressed in platelet membrane. Our objective was to describe the role of P-selectin on endothelial reactivity in patients with pre-eclampsia compared with normal pregnancies.
Material And Methods:
Blood samples from 30 patients with severe pre-eclampsia (cases) were compared with patients with 30 normal pregnancies during labor (controls). Samples from both groups were analyzed using ELISA (Bender Med kit, Vienna, Austria) for determination of P-selectin.
Results:
We compared main clinical, biochemical, and hematologic variables in both groups, identifying an outstanding difference in expression of P-selectin between them.
Conclusions:
P-selectin is a marker of endothelium activation in patients with severe pre-eclampsia.
