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Published on: March 29, 2022
Microcionamides A and B, bioactive peptides from the philippine sponge Clathria (Thalysias) abietina
Rohan A Davis1, Gina C Mangalindan, Zenaida P Bojo
1Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Abstract:
Microcionamides A (1) and B (2) have been isolated from the Philippine marine sponge Clathria (Thalysias) abietina. These new linear peptides are cyclized via a cystine moiety and have their C-terminus blocked by a 2-phenylethylenamine group. Their total structures, including absolute stereochemistry, were determined by a combination of spectral and chemical methods. Compound 1 was shown to slowly isomerize about the C-36/C-37 double bond when stored in DMSO. Microcionamides A (1) and B (2) exhibited significant cytotoxicity against the human breast tumor cells lines MCF-7 and SKBR-3 and displayed inhibitory activity against Mycobacterium tuberculosis H(37)Ra.
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