Supercritical carbon dioxide extraction of griseofulvin from the solid matrix obtained after solid-state fermentation

¹Food and Fermentation Technology Department, Institute of Chemical Technology, University of Mumbai, Matunga, Mumbai 400 019, India.

|June 5, 2004

Summary

Supercritical carbon dioxide extraction offers an eco-friendly method for isolating the antifungal griseofulvin. This green technology approach effectively recovers griseofulvin from solid-state fermentation products.

Area of Science:

Green Chemistry
Biotechnology
Pharmaceutical Science

Background:

Growing global concern over the human carcinogenicity of chlorinated organic solvents.
Increasing demand for environmentally friendly alternatives in chemical processing and green technology.
Supercritical carbon dioxide (SC-CO(2)) extraction as a viable, non-toxic solvent alternative.

Purpose of the Study:

To evaluate the potential of supercritical carbon dioxide extraction (SCFE) for the downstream processing of griseofulvin.
To optimize SCFE conditions for griseofulvin recovery from solid-state fermentation (SSF) matrices.
To demonstrate an eco-friendly method for antibiotic extraction.

Main Methods:

Solid-state fermentation (SSF) to produce griseofulvin.
Supercritical carbon dioxide extraction (SCFE) utilizing optimized parameters.
Analysis of griseofulvin recovery under specific pressure, temperature, and flow rate conditions.

Main Results:

Griseofulvin, with a molecular weight of 353, is suitable for SCFE.
Optimized SCFE conditions: 60°C, 0.4 L/min flow rate, 90 min contact time (30 min static + 60 min dynamic), and 450-455 bar pressure.
Successful extraction of griseofulvin from the solid matrix post-SSF.

Conclusions:

SCFE is a highly effective and green method for griseofulvin downstream processing.
This technique minimizes the use of hazardous organic solvents, aligning with green technology principles.
SCFE provides a promising alternative for the industrial-scale recovery of antifungal compounds like griseofulvin.

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Supercritical carbon dioxide extraction of griseofulvin from the solid matrix obtained after solid-state fermentation

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Supercritical carbon dioxide extraction of griseofulvin from the solid matrix obtained after solid-state fermentation

Area of Science:

Background:

Purpose of the Study:

Main Methods:

Main Results:

Conclusions:

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