Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developing an improved vaccine against tuberculosis.

Helen McShane1

  • 1Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK. helen.mcshane@ndm.ox.ac.uk

Expert Review of Vaccines
|June 5, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lung mucosal and systemic responses at single-cell resolution in an aerosolized Mycobacterium bovis BCG human challenge model.

Cell reports. Medicine·2026
Same author

Domain arrangement-driven immunogenicity of a computationally designed mRNA vaccine targeting PPE68, IrtA, and PE9 of Mycobacterium tuberculosis.

Scientific reports·2026
Same author

Enhancing tuberculosis vaccine efficacy with a heterologous mRNA-ChAdOx1 prime-pull strategy targeting lung-resident memory T cells.

Frontiers in immunology·2026
Same author

The influence of murine cytomegalovirus infection on susceptibility to mycobacterial infection.

iScience·2026
Same author

Evaluation of 1<sup>st</sup> WHO anti-malaria reference reagent for competition ELISA harmonisation and development of ADAMSEL analytical platform.

Biologicals : journal of the International Association of Biological Standardization·2025
Same author

MetE: a promising protective antigen for tuberculosis vaccine development.

Frontiers in immunology·2025
Same journal

Projected health and economic impact of PCV20 vaccination in UK children: a dynamic transmission model.

Expert review of vaccines·2026
Same journal

Evaluating the societal value of adult respiratory vaccination in Sweden: a benefit-cost analysis.

Expert review of vaccines·2026
Same journal

Evaluating the socioeconomic value of adult respiratory immunization in Spain: a benefit-cost analysis.

Expert review of vaccines·2026
Same journal

Whole cell and acellular pertussis vaccines - rethinking the evidence.

Expert review of vaccines·2026
Same journal

Modeling the potential public health and economic impact and cost-effectiveness of vaccination strategies using an adapted COVID-19 vaccine in the Dominican Republic.

Expert review of vaccines·2026
Same journal

Narrative shielding and prebunking: a synergistic strategy against vaccine hesitancy in pediatrics.

Expert review of vaccines·2026
See all related articles

Tuberculosis remains a global health crisis despite an 80-year-old vaccine. This review examines factors behind its resurgence, the limitations of the bacille Calmette-Guérin vaccine, and the development of new tuberculosis vaccines.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Vaccinology

Background:

  • Tuberculosis (TB) continues to be a significant global health problem, causing widespread mortality and morbidity.
  • The existing bacille Calmette-Guérin (BCG) vaccine has been available for over 80 years but has limitations in preventing TB.
  • Factors contributing to the resurgence of TB and the inefficacy of the current vaccine require thorough investigation.

Purpose of the Study:

  • To discuss the factors contributing to the resurgence of tuberculosis.
  • To explore potential reasons for the failure of the bacille Calmette-Guérin vaccine.
  • To consider the nature of protective immunity against Mycobacterium tuberculosis and its implications for new vaccine development.

Main Methods:

  • Literature review and synthesis of existing research on tuberculosis epidemiology.

Related Experiment Videos

  • Analysis of immunological data related to Mycobacterium tuberculosis infection.
  • Discussion of challenges and considerations for advancing novel TB vaccine candidates into clinical trials.

    • Main Results:

    • The review identifies several factors contributing to the ongoing tuberculosis epidemic.
    • Potential explanations for the limited efficacy of the bacille Calmette-Guérin vaccine are discussed.
    • The nature of protective immunity against Mycobacterium tuberculosis is examined in the context of vaccine design.

    Conclusions:

    • Understanding the limitations of current TB control strategies, including the BCG vaccine, is crucial.
    • Further research into protective immunity is essential for developing more effective tuberculosis vaccines.
    • Addressing challenges in clinical trial progression is necessary to bring promising new TB vaccine candidates to fruition.