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Intracranial optic nerve germinoma.

Trimurti D Nadkarni1, Sudhir C Fattepurkar, Ketan I Desai

  • 1Department of Neurosurgery, Mumbai, India. tdnadkarni@hotmail.com

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|June 5, 2004
PubMed
Summary

A rare case of a germinoma exclusively involving the intracranial optic nerve in an 11-year-old boy is presented. This finding is significant as primary optic nerve germinomas are exceptionally uncommon.

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Area of Science:

  • Neuro-oncology
  • Ophthalmology
  • Pediatric Neurology

Background:

  • Germinomas are rare tumors, typically affecting the central nervous system.
  • Optic nerve involvement by germinomas is infrequent, usually occurring with other intracranial sites.
  • Isolated intracranial optic nerve germinomas represent an extremely rare presentation.

Observation:

  • An 11-year-old boy presented with a three-month history of decreased vision in his left eye.
  • Ophthalmic examination revealed light perception vision only in the affected eye.
  • Magnetic resonance imaging showed a thickened left intracranial optic nerve.

Findings:

  • Surgical exploration via pterional craniotomy revealed diffuse thickening of the left optic nerve.
  • Histopathological analysis of a mass along the optic nerve confirmed it to be a germinoma.

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  • This case represents the first reported instance of exclusive primary intracranial optic nerve involvement by a germinoma.

    • Implications:

    • Highlights the importance of considering rare diagnoses in pediatric vision loss.
    • Adds to the understanding of germinoma presentation and behavior.
    • Suggests the need for specific diagnostic and treatment considerations for isolated optic nerve germinomas.