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Published on: May 12, 2023
2-Ureidoquinoline: a useful molecular element for stabilizing single cytosine and thymine bulges
Akio Kobori1, Takashi Murase, Hitoshi Suda
1PRESTO, Japan Science and Technology Agency, Kyoto 615-8510, Japan.
Abstract:
We have demonstrated that aromatic heterocycles having hydrogen-bonding surfaces complementary to those of nucleotide bases are effective molecular elements for the binding to single nucleotide bulges and base mismatches. We here report that a new molecule, 2-ureidoquinoline having an alignment of hydrogen-bonding groups in the order of acceptor-donor-donor stabilizes single cytosine and thymine bulges in duplex DNAs. Furthermore, a dimeric form of 2-ureidoquinoline stabilizes cytosine-cytosine and cytosine-thymine mismatches.
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