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Related Experiment Videos

Cough reflex in allergic dogs.

Aileen House1, Chander Celly, Susan Skeans

  • 1Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.

European Journal of Pharmacology
|June 5, 2004
PubMed
Summary
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Antigen and histamine challenges alter cough reflex characteristics in dogs. Bronchoprovocation increased cough number but decreased cough amplitude, affecting respiratory parameters.

Area of Science:

  • Respiratory Physiology
  • Immunology
  • Pharmacology

Background:

  • Neonatal sensitization to allergens like ragweed can predispose individuals to altered respiratory responses.
  • The cough reflex is a critical defense mechanism, but its modulation by inflammatory stimuli is complex.

Purpose of the Study:

  • To investigate the impact of antigen (ragweed) and histamine challenge on the cough reflex in dogs.
  • To assess changes in respiratory parameters and cough characteristics following bronchoprovocation.

Main Methods:

  • Mechanically induced coughs and respiratory parameters (tidal volume, respiratory rate, pulmonary resistance, dynamic lung compliance) were measured in anesthetized dogs.
  • Dogs were challenged with aerosolized ragweed or histamine after neonatal sensitization.

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  • Cough number and amplitude were quantified by mechanical stimulation of the intrathoracic trachea.

    • Main Results:

    • Aerosolized ragweed and histamine challenges did not induce spontaneous coughs but altered respiratory mechanics (increased respiratory rate and pulmonary resistance, reduced tidal volume and lung compliance).
    • Mechanical stimulation post-challenge resulted in a significantly increased number of coughs but reduced cough amplitude compared to saline control.
    • These changes in cough characteristics returned to baseline within 24-48 hours after ragweed challenge.

    Conclusions:

    • Both antigen and histamine bronchoprovocation modify the mechanically induced cough reflex in dogs.
    • The observed changes manifest as an increased frequency of coughs coupled with a diminished expiratory amplitude.
    • These findings highlight the complex interplay between airway inflammation and the neural control of cough.