Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Postnatal refinement of peripheral olfactory projections.

Dong-Jing Zou1, Paul Feinstein, Aimée L Rivers

  • 1Department of Biological Sciences, Columbia University, New York, NY 10027, USA. dz98@columbia.edu

Science (New York, N.Y.)
|June 5, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A pilot study on aging-related effects on step performance: The role of muscle quality, size, and strength.

Scientific reports·2026
Same author

A microbiome-derived olfactory signal regulates inter-male aggression and social dominance in mice.

Current biology : CB·2026
Same author

The Olfr151 Odorant Receptor Gene is Resistant to Activation in Embryonic Stem Cells.

bioRxiv : the preprint server for biology·2026
Same author

Glomeruli of the Mouse Olfactory Bulb: Numbers, Sizes, Shapes.

The European journal of neuroscience·2025
Same author

Anakinra restores immunological misfiring that drives influenza-associated pulmonary aspergillosis.

Science translational medicine·2025
Same author

A common mechanism of singular gene choice is revealed by broadly expressed odorant receptor transgenes within the olfactory epithelium.

Cell reports·2025

Glomerular maturation in the olfactory bulb depends on sensory input during specific developmental periods. Early-stage heterogeneous glomeruli, normally transient, persist when sensory input is blocked, suggesting prolonged neuron survival.

Area of Science:

  • Neuroscience
  • Olfactory system development
  • Sensory processing

Background:

  • Axonal projections from the olfactory epithelium to the olfactory bulb form structures called glomeruli.
  • Glomerular organization is based on the specific odorant receptor expressed by olfactory sensory neurons.
  • The maturation process of these glomeruli is complex and not fully understood.

Purpose of the Study:

  • To investigate the temporal dynamics of glomerular maturation for different odorant receptors.
  • To determine the role of sensory input and sensitive periods in glomerular development.
  • To examine the persistence of heterogeneous glomerular structures under conditions of sensory deprivation.

Main Methods:

  • Utilized gene-targeted mice to study olfactory system development.

Related Experiment Videos

  • Manipulated sensory input by unilateral naris closure to induce sensory deprivation.
  • Analyzed glomerular organization and neuronal survival at different developmental stages and under experimental conditions.

    • Main Results:

    • Glomerular maturation exhibits distinct time courses for different, yet similar, odorant receptors.
    • Sensory input is crucial during specific sensitive periods for proper glomerular maturation.
    • Heterogeneous glomeruli, where axons from neurons expressing different receptors converge, normally disappear with age.
    • Unilateral naris closure leads to the persistence of these heterogeneous glomeruli in adult mice.
    • Prolonged survival of olfactory sensory neurons may contribute to the persistence of heterogeneous glomeruli.

    Conclusions:

    • Olfactory glomerular development is a dynamic process influenced by the timing of sensory input.
    • Specific sensitive periods exist during development for the correct organization of olfactory bulb circuitry.
    • Sensory experience plays a critical role in eliminating aberrant axonal connections and refining glomerular structure.
    • The persistence of heterogeneous glomeruli under sensory deprivation highlights the dependence of normal circuit refinement on sensory experience and suggests a role for neuronal survival mechanisms.