Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

'Pleural' and pulmonary carcinosarcomas.

F G Mayall1, A R Gibbs

  • 1Department of Histopathology, Llandough Hospital, Penarth, South Glamorgan, U.K.

The Journal of Pathology
|July 1, 1992
PubMed
Summary

Distinguishing pleural carcinosarcomas from mesothelioma is challenging due to similar histology. This study highlights key features to differentiate these rare tumors, aiding accurate diagnosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The gross appearances of fine needle aspiration cytology samples.

Journal of clinical pathology·2008
Same author

The comparative accuracy of different pleural biopsy techniques in the diagnosis of malignant mesothelioma.

Histopathology·2008
Same author

EGFR and PDGFR differentially promote growth in malignant epithelioid mesothelioma of short and long term survivors.

Thorax·2007
Same author

Coexistent atypical adenomatous hyperplasia, primary lung adenocarcinoma and pleural mesothelioma in an asbestos-exposed subject.

Histopathology·2004
Same author

The pathology associated with therapeutic procedures in malignant mesothelioma.

Histopathology·2004
Same author

Inter-observer variation between pathologists in diffuse parenchymal lung disease.

Thorax·2004

Area of Science:

  • Pathology
  • Oncology
  • Thoracic Surgery

Background:

  • Distinguishing between carcinosarcoma and mesothelioma, particularly in pleural tumors, is histologically challenging.
  • Carcinosarcomas and mesotheliomas are rare thoracic malignancies with overlapping features.
  • Accurate differentiation is crucial for appropriate patient management and treatment.

Purpose of the Study:

  • To describe the histology and immunohistochemistry of two pleural carcinosarcomas.
  • To compare these pleural tumors with conventional pulmonary carcinosarcomas and mesothelioma.
  • To identify distinguishing features for accurate diagnosis of pleural carcinosarcomas.

Main Methods:

  • Histological examination of two pleural carcinosarcomas.
  • Immunohistochemical analysis of pleural carcinosarcomas.
  • Comparison with a cohort of 12 pulmonary carcinosarcomas and established mesothelioma features.

Main Results:

  • Pleural carcinosarcomas share histological and immunohistochemical similarities with pulmonary carcinosarcomas.
  • Biphasic histology and gross appearance of pleural carcinosarcomas can mimic mesothelioma.
  • Features like neutral mucin, CEA expression, and squamous/neuroendocrine differentiation indicate carcinosarcoma, not mesothelioma.

Conclusions:

  • Pleural carcinosarcomas are rare and can be mistaken for mesothelioma due to overlapping features.
  • Specific immunohistochemical markers and histological findings are essential for differentiating these tumors.
  • Increased awareness and detailed analysis are necessary for the diagnosis of these rare malignancies.

Related Experiment Videos