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Updated: Aug 24, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
Published on: July 5, 2021
Metastatic neuroblastoma presenting with binocular blindness from intracranial compression of the optic nerves
Juan J Chan Lau1, Jonathan D Trobe, Robert E Ruiz
1Department of Ophthalmology (Kellogg Eye Center), University of Michigan Medical School, Ann Arbor, Michigan 48105, USA.
Abstract:
A 2-year-old boy with blindness as an isolated symptom was found to have no light perception binocularly because of compression of both optic nerves by a neuroblastoma infiltrating the walls of the optic canals and medial sphenoid bone. Imaging disclosed a primary tumor near the kidney and multiple osseous metastases. Although neuroblastoma commonly causes blindness by metastasis to the orbit, it rarely causes bilateral blindness from intracranial compression of the optic nerves. This is the first report of bilateral blindness as the presenting feature.
