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Updated: Feb 9, 2026
04:41
Plaquing of Herpes Simplex Viruses
Published on: November 5, 2021
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[Clinical and diagnostic developments in corneal herpes]
1Service d'Ophtalmologie, CHU Dupuytren, 2, avenue Martin Luther King, 87042 Limoges Cedex. pierre-yves.robert@unilim.fr
Journal Francais D'Ophtalmologie
|June 5, 2004
Summary
Diagnosing herpes keratitis has improved, reducing the need for corneal transplants. However, detecting the virus in donor corneas remains a challenge for preventing transmission.
Area of Science:
- Ophthalmology
- Virology
- Immunology
Context:
- Herpes keratitis, a significant cause of corneal opacity, is increasingly managed non-surgically.
- Corneal manifestations stem from herpes simplex virus (HSV) reactivation or immune responses.
- Meta-herpetic keratitis represents a sequela of HSV infection.
Purpose:
- To review current diagnostic modalities for herpes keratitis.
- To discuss the challenges in detecting infectious HSV in corneal tissues for transplantation.
- To highlight the declining indications for keratoplasty due to improved diagnostics and treatments.
Summary:
- Corneal signs in herpes keratitis result from HSV reactivation or secondary immune responses.
- Diagnostic methods include direct examination, cell culture for infective virus, aqueous humor antibody detection, and HSV DNA PCR.
- HSV transmission via corneal grafts is a concern, with no current tests for infective donor corneas.
Impact:
- Advances in diagnosis and treatment are reducing the need for keratoplasty in herpes keratitis.
- Improved diagnostic techniques aid in differentiating viral reactivation from immune-mediated disease.
- The risk of HSV transmission through corneal grafts necessitates improved screening methods in eye banks.
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