Related Experiment Video
Updated: Aug 3, 2026

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders
Published on: February 3, 2021
Approach to the patient with chest pain and nonobstructive coronary artery disease
1Center for Coronary Physiology and Imaging, Division of Cardiovascular Diseases, Mayo Clinic Rochester, MN 55905, USA.
Insights
Patients with chest pain and nonobstructive coronary artery disease (NOCAD) often strain healthcare resources. A structured diagnostic approach and specialized clinics can improve care and reduce testing for these complex cases.
Area of Science:
- Cardiology
- Diagnostic Medicine
Background:
- Nonobstructive coronary artery disease (NOCAD) presents a diagnostic challenge.
- Patients with chest pain and NOCAD consume significant healthcare resources.
- Current diagnostic and treatment pathways can be lengthy and complex.
Purpose of the Study:
- To propose a simple classification system for chest pain patients with NOCAD.
- To outline a stepwise diagnostic approach to streamline evaluation.
- To highlight the potential benefits of chest pain clinics for this patient group.
Main Methods:
- Review of existing diagnostic protocols for chest pain.
- Development of a proposed classification and stepwise algorithm.
- Analysis of resource utilization in NOCAD patient care.
Main Results:
- A simplified classification system can aid in diagnosis.
- A stepwise approach may reduce unnecessary investigations.
- Chest pain clinics show promise for efficient patient management.
Conclusions:
- Implementing a structured approach can improve the diagnosis and treatment of chest pain in NOCAD patients.
- Specialized chest pain clinics may offer a more efficient and beneficial care model.
- Further research into optimized diagnostic pathways is warranted.
Abstract:
Patients with chest pain and nonobstructive coronary artery disease (NOCAD) utilize a significant part of our health care resources. Their diagnosis and treatment can often be difficult and time consuming. A simple classification system and stepwise diagnostic approach may help to reduce unnecessary testing. Also, utilization of a chest pain clinic may be beneficial for these patients.
More Related Videos
Related Concept Videos
Coronary Artery Disease V: Interprofessional Care
Acute Coronary Syndrome V: Nursing Management
Angina I: Introduction
Angina III: Clinical Manifestations and Assessment
Angina IV: Management
Angina V: Nursing Management

