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Published on: August 15, 2016
[Investigation on release model of insoluble drug in hydroxypropyl methycellulose matrix tablets]
Xiao-wei Ma1, Jing-qun Yuan, Wen-quan Liang
1College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China.
Objective:
To investigate the release model of insoluble drug carbamazepine (CBM) based on HPMC matrix tablets.
Methods:
CBM release profile from matrices and HPMC erosion rate were determined.
Result:
The mathematical model by matrix erosion rate and drug release from HPMC K15M were established for the fractional HPMC and CBM released as M(P(t))/M(P(infinity))=-[0.8095ln((t))+1.2775]Meq((-0.0622t-0.305)) and M(d(t))/M(d(infinity))=-[0.1891t-0.1294]Meq(-0.9326). In comparison with the data of HPMC K4M matrix erosion and CBM release from HPMC K4M matrices, theoretical value agreed well with experimental data.
Conclusion:
The two mathematical models can be satisfactorily applied to insoluble drug release, which is governed by matrix erosion.
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