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Updated: Jul 31, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
[The liver and the nervous system]
1Institute of Experimental Medicine, Russian Academy of Medical Sciences, Academician Pavlov Street., 12, St-Petersburg, 197376, Russia.
Abstract:
This review considers the liver adrenergic and cholinergic innervation in connection with its trophic function. The attempt was made to analyse mechanisms of nervous regulation of liver metabolism and to estimate the role of co-transmitters in metabolic functions of the peptidergic fibers. Liver and portal vein afferent sensors for amino acids, glucose, insulin, glucagon, leptin and osmosensors were described. These sensors detect the liver metabolic signals and transmit them by vagal hepatic afferents to the network of hypothalamic and cortical structures.
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