Related Experiment Video
Updated: Aug 24, 2026

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
[Complication of polyacrylamide hydrogel injection for facial plasty]
Sen-song Kang1, Zheng-wen Zhang, Hai-yan Chou
1Department of Plastic Surgery, Henan Provincial Hospital, Henan 450003, China.
Objective:
To investigate the causes of complications of polyacrylamide hydrogel injection for facial plasty and reliable treatments.
Methods:
Eight patients were included in the study. Some of them were examined by MRI. All the patients received surgical treatments.
Results:
The injected polyacrylamide hydrogel was found in the superficial layer of the superficial temporal fasica, the loose connective tissue below the deep temporal fascia, the subcutaneous tissue or the orbicularis muscle. Polyacrylamide hydrogel injected into the superficial layer of the superficial temporal fascia could spread to the face along the SMAS. Polyacrylamide hydrogel injected into the loose connective tissue below the deep temporal fascia could spread down to the cheek. The patients' symptoms were relieved with the operation. Satisfactory results were obtained.
Conclusion:
Polyacrylamide hydrogel injection does not adapt to facial plasty. The reliability of polyacrylamide hydrogel injection for facial plasty is in doubt.
Insights
Complications from polyacrylamide hydrogel injections for facial plasty were investigated. Surgical treatment relieved symptoms, but the safety and efficacy of this filler for facial procedures remain questionable.
Area of Science:
- Plastic Surgery
- Biomaterials Science
Background:
- Facial plasty utilizes various injectable fillers for aesthetic enhancement.
- Polyacrylamide hydrogel has been employed for facial contouring and augmentation.
Observation:
- Complications arose from polyacrylamide hydrogel migration within facial anatomical layers.
- Hydrogel was found in superficial temporal fascia, subfascial tissues, subcutaneous layers, and muscles.
- Spread occurred along the SMAS to the face and down to the cheek.
Findings:
- Surgical intervention successfully resolved patient symptoms associated with polyacrylamide hydrogel.
- The study identified specific tissue planes prone to filler migration.
- Post-operative outcomes were satisfactory following surgical management.
Implications:
- Polyacrylamide hydrogel's suitability for facial plasty is uncertain due to migration risks.
- The long-term reliability and safety of polyacrylamide hydrogel for facial augmentation require further scrutiny.
- Effective surgical management strategies exist for addressing complications.