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Updated: Aug 24, 2026

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
Published on: June 7, 2015
[Analysis and treatment of complications induced by polyacrylamide hydrogel injection]
Xiao-ling Feng1, Chua-xun Yi, Chong Peng
1Department of Plastic Surgery, Union Hospital, TongJi Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Objective:
To explore the reasons for the complications of polyacrylamide hydrogel injection.
Methods:
39 patients were included in this study, who had complications after polyacrylamide hydrogel injection in the breasts, nose, temproal area or depressed locus. The clinical manifestations of the complications were analyzed.
Results:
Postoperative infection occurred in 5 cases, induration in 23, pain in 25, ulceration of the puncture points in 9, displacement in 6, galactostasis in 1, skin necrosis in 1, breast deformation in 3, bilateral asymmetry in 4, aseptic inflammation in 10, and skin-acne-like changes on the face in 4.
Conclusion:
Some complications were caused mainly by incorrect manipulation and others were relative to the injected material. The applications of polyacrylamide hydrogel as a clinical implant material need further investigations. Polyacrylamide hydrogel injection should be cautiously used.
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