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A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
[A clinical pathological study on cavernous venous malformation of the body surface]
Si-ming Yuan1, Tian-xiang Ouyang, Xin Xing
1Department of Plastic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Objective:
To investigate the clinical pathology of cavernous venous malformations of the body surface.
Methods:
Tissue samples of cavernous venous malformations from 42 cases were stained with hematoxylin and eosin to observe the pathologic structure. The clinical manifestations and case history were summarized accordingly.
Results:
There was no distribution difference of the malformation in sex and body sides, but with obvious difference in anatomic sites. The malformation occurred most frequently at the head and neck, more frequently at extremities and least frequently at the trunk. According to pathologic structure, cavernous venous malformations of the body surface can be divided into three types: the cellular, the canaliform and the mixed.
Conclusion:
The cause of distribution difference in anatomic sites remains unclear. Internal hemorrhage and infection may account for the increased growth and ache of the lesion. The different pathologic structure of the malformation may cause different clinical manifestations.
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