Related Experiment Video
Updated: Aug 24, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
A new wet conductivimetric method to estimate the drug percolation threshold
Alvaro Espina-Márquez1, Isidoro Caraballo
1Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, c/o Professor García González, 2.41012 Seville, Spain.
Purpose:
The main objectives of this work are to study the behavior of fluid imbibition into a consolidated matrix through a wet invasive conductivimetric technique, to investigate if the changes in the behavior observed can be related to the drug percolation threshold, and to use this technique for its estimation.
Methods:
Matrix tablets were prepared using five sieving fractions of KCl and Eudragit RS-PM. In vitro release assays were carried out on 45 batches. The drug percolation thresholds were estimated following the method of Leuenberger and Bonny, and the results were compared to the obtained employing the conductivimetric technique described in this paper.
Results:
The wet conductivimetric technique and the standard method provided similar results for the estimation of the percolation threshold. The presented technique also provides quantitative information about the consolidated matrix.
Conclusions:
A new apparatus has been developed for the study of the conductivimetric behavior of matrix tablets during water uptake. This technique provides measurable parameters of fluid penetration and can be used to estimate the drug percolation threshold, providing similar results to the Leuenberger and Bonny method and being clearly faster.
More Related Videos
10:33A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
Published on: February 23, 2018
10:17High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Related Concept Videos
In Vitro Drug Dissolution: Compendial Testing Models II
Methods for Studying Drug Absorption: In situ
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
In Vitro Drug Dissolution: Alternative Methods
Methods for Studying Drug Absorption: In vitro
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
In Vitro Drug Dissolution: Compendial Testing Models I
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...