Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Deubiquitinating enzymes: their functions and substrate specificity.

Tatiana A Soboleva1, Rohan T Baker

  • 1Ubiquitin Laboratory, Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia.

Current Protein & Peptide Science
|June 8, 2004
PubMed
Summary

Deubiquitinating enzymes (DUBs) remove ubiquitin from proteins, controlling protein degradation and other cellular processes. Recent research highlights their essential regulatory roles in target-specific ubiquitination.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nonchromatin regulatory functions of the histone variant H2A.B in SWI/SNF genomic deposition.

Science advances·2025
Same author

An Improved Method for Purification of the Residual Bodies from the Seminiferous Tubules of Mice.

Current protocols·2023
Same author

H2A.B is a cancer/testis factor involved in the activation of ribosome biogenesis in Hodgkin lymphoma.

EMBO reports·2021
Same author

Validation of a Circulating Tumor-Derived DNA Blood Test for Detection of Methylated BCAT1 and IKZF1 DNA.

The journal of applied laboratory medicine·2020
Same author

Short Histone H2A Variants: Small in Stature but not in Function.

Cells·2020
Same author

Gene editing of the multi-copy H2A.B gene and its importance for fertility.

Genome biology·2019

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Ubiquitination targets proteins for degradation or trafficking.
  • Deubiquitinating enzymes (DUBs) remove ubiquitin, but their roles are less understood.
  • Ubiquitination is a reversible process, with DUBs playing a key part.

Purpose of the Study:

  • To review recent findings on the functions of deubiquitinating enzymes (DUBs).
  • To emphasize the critical role of DUBs in regulating protein ubiquitination.

Main Methods:

  • Literature review of recent studies on DUBs.
  • Analysis of DUBs' involvement in protein degradation and other pathways.

Main Results:

  • DUBs are essential for regulating protein degradation via the 26S proteasome.

Related Experiment Videos

  • DUBs control other ubiquitin-dependent cellular processes.
  • DUBs regulate protein ubiquitination in a target-specific manner.

    • Conclusions:

    • Deubiquitinating enzymes are crucial regulators of protein fate.
    • Understanding DUBs is key to comprehending ubiquitination-dependent cellular functions.